A blockbuster European night awaits at Anfield as Liverpool host Real Madrid in what promises to be one of the standout fixtures of this season’s Champions League. The Reds, fresh off a morale-boosting 2-0 win over Aston Villa that halted their domestic slump, now turn their focus to a Real Madrid side clicking seamlessly under their former player-turned-manager.
Liverpool’s form may have wavered in recent weeks, but under the lights at Anfield — with the crowd in full voice — they’ll back themselves to challenge a Madrid team that has looked unstoppable since the start of the year.
Check out The Betting Professionals’s analysis for Liverpool vs Real Madrid Champions League 2025-26 match on Matchday 4 with best football betting sites and predictions.
Liverpool vs Real Madrid Champions League 2025-26 Match Details
Date: Tuesday, 4th November 2025/Wednesday, 5th November 2025
Time: 08:00 PM (GMT) / 01:30 AM (IST)
Venue: Anfield
Liverpool vs Real Madrid Match Preview Champions League 2025-26
Anfield braces for another European blockbuster as Liverpool face Real Madrid in a high-stakes Champions League clash.
Arne Slot’s side eased the pressure with a 2-0 win over Aston Villa, sparked by Mohamed Salah’s 250th Reds goal, and now look to channel that momentum under the lights. Liverpool’s European form remains strong — 15 straight home wins in the group or league phase — a record they’ll lean on against the Spanish giants.
Xabi Alonso’s Real Madrid arrive in relentless form, winning 13 of 14 games this season and dominating both La Liga and Europe. After a 2-0 loss on their last Anfield visit, Alonso returns to familiar ground with a side brimming with confidence and quality.
A rejuvenated Liverpool versus a rampant Real — the stage is set for another unforgettable Champions League night.
Liverpool vs Real Madrid Team News - Champions League 2025-26
Liverpool Team News
Liverpool’s preparations for Real Madrid’s visit have hit a minor setback, with Alexander Isak missing Monday’s training session and unlikely to feature. On a brighter note, Curtis Jones has returned to full training after sitting out the weekend’s clash.
Arne Slot is expected to stick with his title-winning midfield trio of Dominik Szoboszlai, Alexis Mac Allister, and Ryan Gravenberch — the same combination that delivered against Aston Villa — while Florian Wirtz is set to start from the bench.
At the back, Andy Robertson looks set to continue at left-back ahead of the out-of-form Milos Kerkez, with Conor Bradley retaining his place on the right in Jeremie Frimpong’s absence.
Injury concerns persist, though, with youngsters Jayden Danns, Giovanni Leoni, and Stefan Bajčetić still sidelined.
Liverpool Predicted Lineup
Mamardashvili; Bradley, Konate, Van Dijk, Robertson; Gravenberch, Mac Allister; Salah, Szoboszlai, Gakpo; Ekitike
Real Madrid Team News
Trent Alexander-Arnold’s Anfield return may pass quietly, with the former Red still awaiting his first minutes back from a hamstring injury after being an unused substitute at the weekend.
For Real Madrid, Dani Carvajal’s absence means Federico Valverde is set to fill in at right-back — a role Xabi Alonso praised him for mastering in recent weeks. The visitors will also be without summer signing Franco Mastantuono, who picked up an injury during the 4-0 win over Valencia. Eduardo Camavinga is expected to step in alongside Aurélien Tchouaméni in midfield.
Up front, Vinícius Júnior — fresh from 79 minutes against Valencia and still buzzing after his fiery Clasico display — will link up with the red-hot Kylian Mbappé on the left, a duo ready to test Liverpool’s fragile backline under the Anfield lights.
Real Madrid Predicted Lineup
Courtois; Alexander-Arnold, Militao, Huijsen, Carreras; Valverde, Tchouameni; Guler, Bellingham, Vinicius Jr; Mbappe
Liverpool vs Real Madrid Betting Odds - Champions League 2025-26 Match
In the table below, check out the latest betting odds for the champions league 2025-26 match between Liverpool vs Real Madrid, set to take place at Anfield.
Match Result | Odds on 1xBet |
Liverpool will win the match | 2.428 |
Real Madrid will win the match | 2.782 |
Match will be drawn | 4.095 |
In the 1X2 market on 1xBet, Liverpool are favorites at 2.42, Real Madrid are priced at 2.78, while a draw stands at 4.095.
Liverpool vs Real Madrid - Recommended Bets by TBP
Bet 1: Each Teams to score to two or more - Yes @ 3.04 at 1xBet
Bet 2: Total Goals over 4 - @ 2.59 at 1xBet
Liverpool vs Real Madrid Match Prediction
Liverpool’s defensive frailties out of possession could invite Real Madrid’s fluid attack to thrive in transition. Arne Slot may lean into the Anfield energy, embracing a high-tempo, chaotic battle rather than containment.
A classic under the lights could unfold — with the Reds, buoyed by their weekend win, just edging a thriller.
Prediction: Liverpool 3–2 Real Madrid
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